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| 2025/5/21 | Publication We have published a paper in Journal of Magnetic Resonance presenting a theoretical framework for proton decoupling used in fluorine NMR.Evaluating the effect of 1H decoupling on 19F longitudinal relaxation and signal line shape in 5-Fluorotryptophan. Toyama Y, Takeuchi K, Shimada I. J Magn Reson. 2025 Aug;377:107899. doi: 10.1016/j.jmr.2025.107899 | |
| 2025/8/25 | Publication A paper describing an in-cell NMR technique for the simultaneous analysis of cellular uptake and intracellular target engagement of medium-sized molecules has been published in Analytical Chemistry,Cell Permeability and Target Engagement of Middle-Sized Molecules Quantified by In-Cell NMR. Sukigara Y, Kamoshida H, Tokunaga Y, Fujisaki M, Imai M, Kobayashi Y, Kofuku Y, Ueda T, Shimada I, Takeuchi K. Anal Chem. 2025 Aug 25. doi: 10.1021/acs.analchem.5c01494 | |
| 2025/8/28 | Publication A paper has been published in Nature Communications describing the molecular mechanism by which the RNA helicase DDX3X, which recognizes mRNA and regulates translation, selectively identifies specific mRNAs.https://www.nature.com/articles/s41467-025-62806-7 | |
| 2025/7/31 | Publication Our paper on the target recognition mechanism of a therapeutic drug for age-related macular degeneration has been accepted for publication in the journal RNA.Two-step target recognition for the competitive inhibition activity of an anti-VEGF aptamer. Takeuchi K, Ueda T, Imai M, Fujisaki M, Tsujimura M, Tokunaga Y, Kofuku Y, Shimada I. RNA. 2025 Jul 31:rna.080524.125. doi: 10.1261/rna.080524.125 | |
| 2025/6/17 | Publication A groundbreaking NMR method for observing the aromatic side chains of ultra-high molecular weight proteins was published a paper in Nature Chemistry.Leveraging relaxation-optimized 1H-13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. *Boeszoermenyi A, Radeva DL, Schindler S, Valadares V, Padmanabha Das KM, Dubey A, Viennet T, Schmitt M, Kast P, Gelev VM, Stoyanov N, Burdzhiev N, Petrov O, Ficarro S, Marto J ... Read more |
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| Laboratory name | Graduate School of Pharmaceutical Sciences, the University of Tokyo Laboratory of Physical Chemistry |
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| Address | 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Pharmaceutical Sciences Research Building, 2nd floor |
| Tel & Fax | +81-(3)-5841-4811 |
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