News

2025/8/28

Publication A paper has been published in Nature Communications describing the molecular mechanism by which the RNA helicase DDX3X, which recognizes mRNA and regulates translation, selectively identifies specific mRNAs.

https://www.nature.com/articles/s41467-025-62806-7

2025/8/25

Publication A paper describing an in-cell NMR technique for the simultaneous analysis of cellular uptake and intracellular target engagement of medium-sized molecules has been published in Analytical Chemistry,

Cell Permeability and Target Engagement of Middle-Sized Molecules Quantified by In-Cell NMR.
Sukigara Y, Kamoshida H, Tokunaga Y, Fujisaki M, Imai M, Kobayashi Y, Kofuku Y, Ueda T, Shimada I, Takeuchi K.
Anal Chem. 2025 Aug 25. doi: 10.1021/acs.analchem.5c01494

2025/7/31

Publication Our paper on the target recognition mechanism of a therapeutic drug for age-related macular degeneration has been accepted for publication in the journal RNA.

Two-step target recognition for the competitive inhibition activity of an anti-VEGF aptamer.
Takeuchi K, Ueda T, Imai M, Fujisaki M, Tsujimura M, Tokunaga Y, Kofuku Y, Shimada I.
RNA. 2025 Jul 31:rna.080524.125. doi: 10.1261/rna.080524.125

2025/6/17

Publication A groundbreaking NMR method for observing the aromatic side chains of ultra-high molecular weight proteins was published a paper in Nature Chemistry.

Leveraging relaxation-optimized 1H-13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins.
Boeszoermenyi A, Radeva DL, Schindler S, Valadares V, Padmanabha Das KM, Dubey A, Viennet T, Schmitt M, Kast P, Gelev VM, Stoyanov N, Burdzhiev N, Petrov O, Ficarro S, Marto J, Geffken EA, Dhe-Paganon S, Seo HS, Alexander ND, Cooley RB, Mehl RA, Kovacs H, Anklin C, Bermel W, Kuprov I, Takeuchi K, *Arthanari H.
Nat Chem. 2025 Jun;17(6):835-846. doi: 10.1038/s41557-025-01818-8

2025/5/21

Publication We have published a paper in Journal of Magnetic Resonance presenting a theoretical framework for proton decoupling used in fluorine NMR.

Evaluating the effect of 1H decoupling on 19F longitudinal relaxation and signal line shape in 5-Fluorotryptophan.
Toyama Y, Takeuchi K, Shimada I.
J Magn Reson. 2025 Aug;377:107899. doi: 10.1016/j.jmr.2025.107899

2025/4/25

Award Yota Sukigara (M2) was awarded Best Student Presentation Award (poster) in the 145th Annual Meeting of the Pharmaceutical Society of Japan.

2024/10/31

Award Keita Shigemi (M1) was awarded poster prize in 63th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan.

2024/9/1

Notice We welcome a assistant professor, Yuki Toyama as a new faculty member of our lab.

2024/8/8

Publication A paper elucidated the proton/substrate antiport mechanism of a multidrug efflux transporter has been published.

Affinity-directed substrate/H+-antiport by a MATE transporter.
Takeuchi K, Ueda T, Imai M, Fujisaki M, Shimura M, Tokunaga Y, Kofuku Y, Shimada I.
Structure. 2024 Aug 8;32(8):1150-1164.e3. doi: 10.1016/j.str.2024.05.004.

2024/6/1

Notice Dr. Yutaka Kofuku was promoted to lecturer (a position equilibrant to an associate professor)